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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are typically focused on the practical aspects of the study design, such as the recruitment and consent process, adherence, and the use of routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and had participants from different geographic areas. This kind of heterogeneity is essential for pragmatic trials to be valid and reduces bias in the results. However, too much heterogeneity can cause issues with the design of the trial.

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The aim of pragmatic trials is to mimic real-life scenarios and gain the highest level of validity externally. They are usually requested by policy makers and practitioners to aid in their decision-making. They are also a good method of determining the causality between the intervention and its effects. However, 프라그마틱 정품인증 프라그마틱 슬롯 무료체험 사이트; simply click the next internet site, they shouldn't be used in lieu for explanatory trials.

The pragmatism idea is controversial, and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the clinical or physiological hypothesis as well as pragmatic trials, which inform policy and practice decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a practical study, including recruitment, design, implementation of the intervention, and follow-up.

There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This is an indication that the health science community is becoming increasingly sensitized to the issue of pragmatic thinking. It is important to note, however, that the majority of these studies were conducted in primary-care settings.