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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are usually focused on practical aspects of the study design, including recruitment and consent as well as adherence to the use of standard equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and had participants from different geographical regions. This type of heterogeneity which is vital for pragmatic trials to be reliable and lessen the chance of bias is also essential. Too much heterogeneity, however can result in problems with the design of the trial.

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Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are typically commissioned by policy makers and 프라그마틱 슬롯 무료체험 practitioners to aid in their decision-making. They can also be used to determine the cause-effect relationship of an intervention and its results. They should not, however be used to replace the need for explanation studies.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials can replace tests for explanations or if they should be a complement to them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which support the physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the decision-making process for policy and practice. They also proposed an approach to pragmatic trials, dubbed PRECIS.2 This tool sought to define the characteristics of a practical trial, including the recruitment process, the design and delivery of the intervention, as well as the follow-up.

There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to remember that the majority of these studies were conducted in primary care settings.