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Pragmatic trials are studies designed to provide information for the practice of clinical trials in real life. They are often described as focusing on practical aspects of design that include the recruitment process and consent, adhering and the use routinely available equipment.

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A pragmatic trial that uses various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is essential for a pragmatic trial to be reliable and to reduce bias in the results, is also necessary. However, too much heterogeneity can result in problems with the design of the trial.

Pragmatic Play Pragmatic Play, one of the major players in the live casino market offers an array of traditional table games such as Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta offer customers an authentic gambling experience, and a wide variety of betting options via virtual. The company also offers a variety of games that make online gambling more enjoyable and engaging. Some of these shows are broadcast live, while others include famous people from the field.

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The purpose of pragmatic trials is to simulate real-life scenarios and gain the highest level of validity externally. They are usually requested by practitioners and policymakers in order to guide their decisions. They can also be used to determine the causality of an intervention and its results. However, they should not, be used to replace explanation studies.

The idea of pragmatism is controversial and there are doubts about whether pragmatic trials can replace tests for explanations or if they should be a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate a physiological or clinical hypothesis as well as pragmatic trials, which inform the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a practical study that includes recruitment, design, implementation of the intervention, and follow-up.

There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline search using the keywords naturalistic and pragmatic, limited to randomized controlled trials (RCTs), yielded 34 articles, as shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to note that the majority of these studies were conducted in primary care settings.