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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are usually focused on the practical aspects of research design, like the recruitment process and consent in adherence, as well as the use of commonly available equipment.

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Pragmatic is a software development company that offers a broad range of casino games available on online gambling platforms. Pragmatic's iGaming software is used by the top operators as well as land-based casinos. The company provides front-end site design tools, analysis tools and promotions, marketing, security payment systems, customer support, and bug reporting. The company also provides security, high-quality graphics, gaming and security.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and included participants from various geographical areas. This type of heterogeneity is necessary for pragmatic trials to be valid, and it also reduces bias in the results. However excessive heterogeneity could lead to problems with the design of the trial.

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Pragmatic Play is known for its top-quality games and for offering an exceptional user experience. Its software is designed to work on mobile devices and is compatible with different languages. Despite its infancy, it has already established itself as a top gaming platform for casinos. The latest releases include Wolves which is a five-reel video slot with a healthful RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.

The goal of pragmatic trials is to mimic real-life situations and achieve maximum credibility externally. They are usually requested by practitioners and policy makers to aid in their decision-making. They can also be used to assess the cause-effect relationship of an intervention and its results. They should, however, not be used to replace the need for explanation studies.

The pragmatism idea is controversial, and there are questions about whether pragmatic trials can be used to replace explanation tests or if they are an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm the clinical or physiological hypothesis and pragmatic trials, which inform the practice and policy decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the traits of a practical study which includes recruitment, design, implementation of the intervention and follow-up.

There is a positive trend in the number of pragmatic trials that are published. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This is a sign that the health sciences community is becoming more acquaint to the subject of pragmatics. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.