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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often described by their focus on practical aspects of study design, including the recruitment process and consent, adhering and the use of standard equipment.

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A pragmatic study that involves different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for pragmatic trials to be valid and reduces bias in the results. However, too much heterogeneity could cause issues with the design of the trial.

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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are typically commissioned by practitioners and 프라그마틱 무료 슬롯 데모 (Suggested Internet site) policy makers to guide their decision-making. They are also a good method of determining the causal relationship between an intervention and 프라그마틱 슬롯 무료체험 its results. They should, however, not be used to replace explanation studies.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 made a distinction between explanatory studies, which prove the validity of a physiological or clinical hypothesis, as well as pragmatic trials, which inform the practice and policy decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic study which includes recruitment, design, delivery of the intervention and its follow-up.

The number of pragmatic trials is increasing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more acquaint to the subject of pragmatics. It is important to remember that the majority of these studies were conducted in primary care settings.