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Pragmatic trials are those that are designed to inform the practice of clinical trials in real life. They are typically described as focusing on practical aspects of study design which include recruitment and consent, adherence and the use of routinely available equipment.

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A practical trial that employs different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, that is crucial for pragmatic trials to be valid and reduce bias in results is also essential. However, too much heterogeneity can result in problems with the trial design.

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The purpose of pragmatic trials is to mimic real-life situations and achieve the highest level of validity externally. They are usually requested by policy makers and practitioners to inform their decision making. They are also a good method to determine the causal relationship between an intervention and its outcomes. They should, 프라그마틱 무료 however, not, be used to replace the need for explanation studies.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials can replace tests for explanations or if they should be an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the clinical or physiological hypothesis and pragmatic trials, which guide the practice and policy decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the traits of a practical study, including the recruitment, design, and delivery of the intervention and its follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This is an indication that the health sciences community is becoming more acquaint to the subject of pragmatism. It is important to remember that the majority of these studies were conducted in primary care settings.