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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often described by their focus on practical aspects of design which include recruitment and consent, adherence and the use of routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed various investigators and included participants from various geographical areas. This type of heterogeneity is essential for practical trials to be valid and also helps reduce the chance of bias in the results. Too much heterogeneity, however can result in problems with the design of the trial.

Pragmatic Play Pragmatic Play, one of the biggest players on the live casino market offers various classic table games like Blackjack and Roulette. Pragmatic Play's live studios in Romania and Malta offer an authentic gaming experience for its customers and offer a full suite of virtual betting options. The company also offers a variety of game shows that make online gambling fun and interactive. Some of these shows are telecast live and 프라그마틱 슬롯 무료체험 프라그마틱 이미지 (Scientific-Programs.science) others are hosted by famous personalities from the field.

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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are usually requested by policy makers and practitioners to aid in their decision-making. They can also be used to assess the causality of an intervention with its outcomes. They should not, however be used to replace explanatory studies.

The concept of pragmatism is controversial and there are concerns regarding whether pragmatic trials could replace tests for explanations or if they should serve as an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the validity of a clinical or physiological hypothesis, and pragmatic trials, which guide the practice and policy decisions. They also suggested the framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the characteristics of a pragmatic trial that include recruitment, design and delivery of the intervention, and follow-up.

There is a growing increase in the number pragmatic trials that are published. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more acquaint to the subject of pragmatic thinking. It is important to note that the majority of these studies were conducted in primary care settings.